Design and Optimization of the Circulatory Cell-Driven Drug Delivery Platform

Figure 5

(a) Scheme of gene/chemotherapy on a blood exosome basis. Chemotherapeutic drugs and the cholesterol-modified miRNA21 inhibitor were embedded between the vesicle lipid bilayers for tumor killing; both magnetic molecules and L17E peptides were bound onto the vesicle membrane, respectively, for targeting and lysosome escape. (b) According to nanoparticle tracking analysis (NTA), the original exosome size was 93 nm. (c) The size was increased to 106 nm on average, after cargo loading and membrane modification, and transmission electron microscope (TEM) images showed modified exosomes that retained a clustered structure. Reproduced with permission [90]. Copyright 2020. Ivyspring International Publisher.

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