Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic Peripheral Neuropathy

Figure 5

Effect of MSC on the levels of MDA and nitrite in the sciatic nerves and dorsal root ganglia of mice with OXL-induced chronic neuropathy. Two weeks after the OIPN model induction, mice were treated with MSC (OXL+MSC) or vehicle (OXL+vehicle) by endovenous route. Control group received 5% dextrose instead of OXL. The levels of MDA and nitrite in the sciatic nerve (a, b, respectively) and DRG (c, d, respectively) were measured 4 weeks after treatment. Data are expressed as ; mice per group. Statistical significance relative to the control group (); ^#statistical significance relative to the OXL+vehicle group (), as determined by one-way ANOVA followed by Tukey’s multiple comparison test.

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