Adventitial Progenitor Cells of Human Great Saphenous Vein Enhance the Resolution of Venous Thrombosis via Neovascularization

Figure 5

The organization and neovascularization of thrombi in control and treatment groups at postoperative days 7 and 14 (). T indicates thrombus, and the black arrow indicates positive cells. A1–A4, The HE staining, and A indicates artery. B1–B4, Immunohistochemical staining with CD31 antibody. C1–C4, Immunohistochemical staining with F4/80 antibody. As venous thrombi organization progressed, the monocytes and the endothelial cells entered into the thrombus, wherein the neovascularization appeared. D1–D4, The organization area, thrombus cell counts, the number of endothelial cells, and macrophages in control and treatment groups, respectively. Significant differences between control and treatment group, . Significant differences between control and treatment group, . T: area of thrombi; W: area of vein wall. Scale bars: 100 μm (A1–A4); 15 μm (B1–C4). Magnification: 40x (A1–A4), 400x (B1–C4).