Review Article

An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases

Table 1

MSC-based clinical trials for cutaneous diseases.

ClinicalTrials.gov identifierPhase/status/(start dates)ConditionsType of cellsOutcomeCountry

NCT02824393Early phase 1
Completed
(March 2017)
UrticariaAutologous MSCsMSC therapy more effective than conventional treatment, resulted in longer recoveryTurkey
NCT01771679Phase 1
Phase 2
Suspended
(July 2015)
PhotoagingAllogeneic BMSCsOngoingUnited States
NCT03765957Early phase 1
Not yet recruiting
(February 2019)
PsoriasisMSCsOngoingChina
NCT02304562Phase 1
Unknown
(January 2013)
Sweat gland diseasesUCB-MSCsOngoingChina
NCT02491658Phase 1
Phase 2
Unknown
(April 2015)
Psoriasis vulgarisUC-MSCsOngoingChina
NCT02213705Phase 1
Phase 2
Unknown
(May 2014)
Systemic sclerodermaAllogeneic MSCsOngoingFrance
NCT03745417Phase 1
Phase 2
Recruiting
(August 2018)
PsoriasisUC-MSCsOngoingChina
NCT03265613Phase 1
Phase 2
Active, not recruiting
(September 2017)
PsoriasisADSCsOngoingChina
NCT03564808Phase 2
Recruiting
(June 2018)
Skin pigmentation over contour deformities of the face, trauma, Romberg’s diseaseMSCsOngoingPakistan
NCT03392311Phase 1
Phase 2
Recruiting
(August 2019)
PsoriasisADSCsOngoingChina
NCT03424629Phase 1
Unknown
(June 2018)
Moderate and severe plaque psoriasisUC-MSCsOngoingChina
NCT00962923Phase 1
Phase 2
Unknown
(August 2009)
Systemic sclerosisAllogeneic MSCsOngoingChina
NCT04275024Not applicable
Recruiting
(April 2020)
PsoriasisADSCsOngoingChina
NCT02034786Phase 1
Unknown
(March 2015)
Aesthetics procedureAutologous MSCsOngoingBrazil
NCT02685722Phase 1
Completed
(January 2012)
Skin ulcersUC-MSCsChina
NCT04356287Phase 1
Phase 2
Not yet recruiting
(October 2020)
Systemic sclerosisUC-MSCsOngoing
NCT04520022Phase 1
Phase 2
Completed
(October 2016)
Recessive dystrophic epidermolysis bullosaUC-MSCsKorea
NCT02975960Not applicable
Completed
(October 2016)
Systemic sclerosisAutologous ADSCsKorea
NCT04153630Phase 1
Phase 2
Active, not recruiting
(May 2018)
Recessive dystrophic epidermolysis bullosaBMSCsOngoingSpain
NCT03529877Phase 1
Phase 2
Recruiting
(January 2019)
Recessive dystrophic epidermolysis bullosaAllogeneic ABCB5-positive MSCsOngoingUnited States, Austria, France, German, Italy, United Kingdom
NCT02888704Phase 1
Completed
(July 2016)
Atopic dermatitisMSCsKorea
NCT03887208Phase 1
Phase 2
Completed
(January 2018)
Skin, scar, cutis laxa, keloid, cicatrixAutologous ADSCsPoland
NCT02494752Not applicable
Unknown
(August 2015)
Romberg’s disease, craniofacial microsomia, lipodystrophy, mixed connective tissue diseaseFat graft enriched with MSCsOngoingUnited Kingdom
NCT01033552Phase 2
Recruiting
(January 2010)
Epidermolysis bullosaMSCsOngoingUnited States
NCT02582775Phase 2
Recruiting
(March 2016)
Epidermolysis bullosaAllogeneic MSCsOngoingUnited States
NCT02834858Phase 1
Unknown
(January 2016)
Peripheral vascular disease, ischemia, diabetic footUC-MSCsOngoingChina
NCT01216865Phase 1
Phase 2
Unknown
(January 2011)
Diabetic foot, critical limb ischemiaUC-MSCsOngoingChina
NCT04464213Phase 1
Not yet recruiting
(August 2020)
Diabetic foot ulcerpMSCsOngoing
NCT04432545
Available
(-)
Diffuse cutaneous systemic sclerosis with refractory pulmonary involvementAllogeneic MSCsOngoingChina
NCT01932021Not applicable
Unknown
(April 2013)
Skin ulcerADSCsOngoingFrance
NCT02304588Phase 1
Unknown
(January 2013)
Diabetic foot, lower limb ischemiaMSCsOngoingChina
NCT03259217Phase 1
Unknown
(October 2017)
Diabetic foot ulcersMSCs seeded in chitosan scaffoldOngoingEgypt
NCT04104451Phase 1
Recruiting
(November 2019)
Diabetic foot ulcerCLMSCsOngoingUnited States
NCT00955669Phase 1
Completed
(August 2009)
Diabetic critical limb ischemia and foot ulcerAutologous BMSCsEffective treatment and no recurrence in the next 10-year follow-up spanChina
NCT04466007Phase 2
Not yet recruiting
(October 2020)
Diabetic foot with critical limb ischemiaAllogeneic ADSCsOngoing
NCT03676400Not applicable
Completed
(October 2018)
Androgenic alopeciaUC-MSCsKorea
NCT02672280Phase 1
Phase 2
Unknown
(May 2016)
Wounds, diabetic foot ulcers, burnsMedical collagen membrane with MSCsOngoingChina
NCT03865394Phase 1
Phase 2
Recruiting
(September 2018)
Diabetic foot ulcerAutologous ADSCsOngoingPoland
NCT04497805Phase 2
Not yet recruiting
(August 2020)
Diabetic foot ulcerAllogeneic ADSCsOngoing
NCT03013049Not applicable
Unknown
(January 2016)
VitiligoDMSCsOngoingIndia
NCT02579369Phase 1
Phase 2
Unknown
(October 2015)
Dystrophic epidermolysis bullosaAllogeneic MSCsOngoingKorea
NCT02619877Phase 2
Completed
(October 2015)
Diabetic foot ulcerAllogeneic ADSCsComplete wound healing in the majority of patientsKorea
NCT02796079Phase 1
Unknown
(January 2015)
Peripheral vascular disease, ischemia, diabetic footMSCsOngoingChina
NCT03370874Phase 3
Unknown
(July 2018)
Diabetic foot ulcerAllogeneic ADSCsOngoingKorea
NCT03183726
Completed
(January 2016)
Diabetic foot ulcerAllogeneic ADSCsKorea
NCT03754465Phase 2
Recruiting
(November 2018)
Diabetic foot ulcerAllogeneic ADSCsOngoingUnited States
NCT03629002
Unknown
(September 2018)
Systemic sclerodermaMSCsOngoingFrance
NCT03060551Early phase 1
Completed
(July 2018)
Systemic sclerosisAutologous ADSCsImprovement of skin fibrosis, hand edema, active ulcers, and quality of lifeKorea
NCT03183804
Unknown
(June 12, 2017)
Diabetic foot ulcerAllogeneic ADSCsOngoingKorea
NCT03248466Early phase 1
Recruiting
(August 2017)
Diabetic foot ulcerBMSCsOngoingChina
NCT03257098Phase 1
Phase 2
Recruiting
(November 2017)
Skin ulcer venous stasis chronicAllogeneic ABCB5-positive MSCsOngoingGermany
NCT03252340
Active, not recruiting
(September 2017)
Atopic dermatitisMSCsOngoingKorea
NCT02918123Phase 1
Recruiting
(January 2018)
PsoriasisAllogeneic UCB-MSCsOngoingKorea
NCT03183934
Unknown
(July 2017)
Dystrophic epidermolysis bullosaAllogeneic ADSCsOngoingKorea
NCT04173650Phase 1
Phase 2
Not yet recruiting
(September 2020)
Dystrophic epidermolysis bullosaMSC-EVsOngoing
NCT03211793Phase 1
Phase 2
Unknown
(November 2018)
Systemic sclerosis
Digital ulcer
MSCsOngoingNetherlands
NCT01065337Phase 2
Completed
(August 2005)
Diabetic footBMSCsImprovement of microcirculation and complete wound healing in the majority of patientsGermany
NCT01686139Phase 1
Unknown
(March 2016)
Diabetic foot ulcersMSCsOngoingIsrael
NCT04179760Phase 1
Phase 2
Recruiting
(March 2020)
Atopic dermatitisAllogeneic BMSCsOngoingKorea
NCT02394886Phase 1
Completed
(November 2014)
Diabetic foot ulcerAllogeneic ADSCsKorea
NCT028310752Phase 1
Unknown
(January 2015)
Diabetic footADSCsOngoingChina
NCT04569409Phase 3
Recruiting
(July 2020)
Diabetic foot ulcerAllogeneic ADSCsOngoingKorea
NCT03276312Not applicable
Completed
(April 2015)
Diabetic footAutologous ADSCsImprovement of healing rateItaly
NCT00815217Not applicable
Unknown
(February 2009)
Diabetic woundsAutologous ADSCsOngoingUnited States
NCT04137562Phase 2
Recruiting
(December 2019)
Atopic dermatitisADSCsOngoingKorea
NCT02742844Phase 1
Phase 2
Terminated
(August 2016)
Skin ulcer venous stasis chronicABCB5-positive MSCsOngoingGermany
NCT02619734Phase 1
Unknown
(August 2006)
Chronic leg ulcer
Sickle cell disease
Autologous BMSCsOngoing