Mesenchymal Stem Cells Enhance Therapeutic Effect and Prevent Adverse Gastrointestinal Reaction of Methotrexate Treatment in Collagen-Induced Arthritis

Figure 2

Combined use of UCs and MTX reduced the levels of inflammatory cytokines and rheumatoid factors. (a) Representative images of immunohistochemical staining in joints of CIA mice. The MTX+UC group reduced the expression of IL-1β and TNF-α accumulated in joints compared to the other three groups. Serum levels of TNF-α (b), IL-1β (c), and rheumatoid factor (d) were measured by ELISA. Scale bar, 100 μm. per group. Data are shown as . ; ; ; ns: not significant ().

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