Mesenchymal Stem Cells Enhance Therapeutic Effect and Prevent Adverse Gastrointestinal Reaction of Methotrexate Treatment in Collagen-Induced Arthritis

<div>Combination of UCs and MTX ameliorated side effects of MTX. (a) Representative images of H&amp;E staining of intestinal sections of four groups. Combined application of MTX and UCs to CIA mice downregulated the content of LPS (b) and IL-12 (c) in serum compared to CIA mice treated by MTX. (d) Using UCs or combination of MTX and UCs to treat CIA mice promoted the expression of IL-22 in serum compared to CIA mice treated by MTX. (e) Apoptosis of MODE-K treated by MTX and cocultured with UCs was analyzed by flow cytometry. (f) Proliferation of MODE-K treated by MTX and cultured with UCs was assessed by EdU analysis. 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Stem Cells International

fig3

Figure 3

Figure 3: Mesenchymal Stem Cells Enhance Therapeutic Effect and Prevent Adverse Gastrointestinal Reaction of Methotrexate Treatment in Collagen-Induced Arthritis 

Figure 3 | Mesenchymal Stem Cells Enhance Therapeutic Effect and Prevent Adverse Gastrointestinal Reaction of Methotrexate Treatment in Collagen-Induced Arthritis 