Research Article
Mesenchymal Stem Cells Enhance Therapeutic Effect and Prevent Adverse Gastrointestinal Reaction of Methotrexate Treatment in Collagen-Induced Arthritis
Figure 5
MTX prefers to facilitate macrophage polarization to M2 type. (a) MTX induced an increase of M2 macrophage polarization in a concentration-dependent manner in vitro. (b) The proportion of M2 phenotype macrophages in four groups was analyzed by flow cytometry. (c) The quantification showed that both MTX-treated macrophages and MTX+UC-treated macrophages showed more proportion of CD206-positive cells than macrophages cocultured with UCs. per group. Data are shown as . ; ; ; ns: not significant ().
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