Inhibition of Notch Signaling Promotes the Differentiation of Epicardial Progenitor Cells into Adipocytes

Figure 5

The dynamic changes of Notch signaling in mouse epicardium. (a) The dynamic changes of Jagged-1 in mouse epicardium at different ages. Jagged-1 was mainly expressed in the heart of E11.5 and neonatal mice. (b) The dynamic changes Notch-1 in mouse epicardium at different ages. Notch-1 expression in the mouse epicardium gradually decreased from E11.5 to postnatal 8-week-old mice. (c) The dynamic changes of NICD (activated Notch-1) in epicardium in mice at different ages. NICD was found in epicardium at E11.5 and neonatal mouse but not found in epicardium at postnatal 2-, 4-, and 8-week-old mice.