Pluripotency of Dental Pulp Cells and Periodontal Ligament Cells Was Enhanced through Cell-Cell Communication via STAT3/Oct-4/Sox2 Signaling

Table 5

List of genes with altered expression with PDLCs with indirect coculture.

Gene name	Gene symbol	Fold difference (DPCs/PDLCs vs. PDLCs)	value	Functional gene grouping
Signal transducer and activator of transcription 3 (acute-phase response factor)	STAT3	10.06	0.0031	Induced pluripotent and embryonic stem cell; Organ morphogenesis; Neurogenesis
Homeobox C10	HOXC10	9.66	0.0069	Segmentation/axis/symmetry; Embryonic development; Neurogenesis
Homeobox A9	HOXA9	8.84	0.0057	Segmentation/axis/symmetry; Embryonic development
Enhancer of zeste homolog 2 (Drosophila)	EZH2	6.92	0.0009	Cell growth; Resistance to apoptosis
Estrogen receptor 1	ESR1	4.66	0.0093	Oncogenesis
SRY- (sex determining region Y-) box 2	SOX2	4.36	0.0024	Somatic stem cell maintenance; Induced pluripotent and embryonic stem cell; Embryonic development; Organ morphogenesis; Neurogenesis; Osteogenesis
Octamer-binding transcription factor 4	OCT-4	3.85	0.0082	Somatic stem cell maintenance; Induced pluripotent and embryonic stem cell
Distal-less homeobox 2	DLX2	3.25	0.0442	Embryonic development; Organ morphogenesis; Neurogenesis
Peroxisome proliferator-activated receptor gamma	PPARG	3.14	0.0012	Placenta development; Organ morphogenesis; Neurogenesis
Kruppel-like factor 4 (gut)	KLF4	3.03	0.0095	Embryonic development; Ectoderm, endoderm, and mesoderm formation and differentiation; Organ morphogenesis
Paired box 1	PAX1	-7.32	0.0121	Organ morphogenesis
Nanog homeobox	NANOG	-5.21	0.0139	Somatic stem cell maintenance; Induced pluripotent and embryonic stem cell; Embryonic development
Homeobox A 7	HOXA7	-4.75	0.0204	Segmentation/axis/symmetry; Embryonic development; Ectoderm, endoderm, and mesoderm formation and differentiation
Paired box 5	PAX5	-4.39	0.0232	Organ morphogenesis