Phase I Trial of Intra-arterial Administration of Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Multiple System Atrophy

Figure 2

Brain magnetic resonance imaging (MRI) findings in patient S-103. (a) T2-weighted images. The brain MRI revealed findings consistent with multiple system atrophy including atrophy in the pons, middle cerebellar peduncle, and cerebellum. (b) Diffusion-weighted images on the day following the intra-arterial mesenchymal stem cells. Acute ischemic lesions were not observed. (c) Fluid-attenuated inversion recovery (FLAIR) with enhancement images on the day following the intra-arterial mesenchymal stem cells. Leptomeningeal enhancement occurred in the cerebellar folia along with enhancement in the right superior colliculus and right thalamus (yellow arrows). (d) FLAIR images four days after the procedure. The follow-up brain MRI demonstrated resolved hyperintensity in the right superior colliculus and right thalamus.

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