Review Article
Progress in Mesenchymal Stem Cell Therapy for Ischemic Stroke
Table 1
Advantages and disadvantages of different MSC transplant approaches.
| Routes | Advantages | Disadvantages | Reference |
| Intraparenchymal | Highest homing rate; low off-brain side effect | Highly invasiveness; additional brain tissue damage | [27, 124] | Intraventricular/intrathecal | Allow for migration to different parts of CNS; high homing rate | Invasiveness | [126] | Intravenous | Low invasiveness; easy operation | Stagnation in peripheral tissue; pulmonary embolism | [128, 129] | Intra-arterial | Low invasiveness; considerable homing rate | Microvascular occlusion | [130, 132] | Intraperitoneal | Low invasiveness; high survival rate | Low homing rate | [116, 134] | Intranasal | Noninvasiveness; easy operation; repeated administration | Lack of clinical trial evidence | [136ā138] |
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