Stem Cells International

Review Article

Strategies to Improve the Efficiency of Transplantation with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke: A Review of Recent Progress

Table 1

Recent studies reporting physical approaches that can improve the efficiency of MSC transplantation in ischemic stroke models.
Physical approachesPossible mechanismsAnimal modelSource of MSCResearch timeReferences
Hypoxic pretreatmentPromoting cell homing by CXCL12/CXCR4 signaling pathway.Rat cerebral infarction modelBone marrow (rat)2019Hu et al. [39]
Hypoxic pretreatmentPromoting the migration and integration of MSCs by PI3K/AKT and HIF-1α/CXCR4 pathwaysRat cardiac arrest-induced global cerebral ischemia modelBone marrow (rat)2017Wang et al. [43]
Hypoxic pretreatmentImproving survival and inhibiting apoptosis by inhibiting of caspase-3 activation and increasing expression of HIF-1αRat cerebral infarction modelBone marrow (rat)2017Chen et al. [41]
Hypoxia/reoxygenation pretreatmentPromoting cell migration and increasing their ability to rescue ischemic cortical neurons.Cell model of cerebral ischemiaBone marrow2015Kim et al. [42]
Hypoxic pretreatmentPromoting the expression of trophic/growth factors and improving regenerative responses.Rat cerebral infarction modelBone marrow (rat)2012Wei et al. [40]
p5 peptide loadedPromoting survival of transplanted MSCsRat cerebral infarction modelAdipose (human)2020Paudyal et al. [49]
Three-dimensional aggregationPromoting the migration and resistance to oxidative stress by PI3K/AKT pathwayRat cerebral infarction modelBone marrow (human)2019Yuan et al. [48]
Ultrasound-targeted microbubblePromoting the migration of MSCsRat cerebral infarction modelBone marrow (rat)2019Qian et al. [46]
Ultrasound microvesiclePromoting the migration of MSCsRat cerebral infarction modelBone marrow (rat)2017Chang et al. [47]