Stem Cells International

Review Article

Strategies to Improve the Efficiency of Transplantation with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke: A Review of Recent Progress

Table 2

Recent studies reporting chemical agents that can improve the efficiency of MSC transplantation in ischemic stroke models.
Chemical agentsPossible mechanismsAnimal modelSource of MSCResearch timeReferences
VX-765Improving the cell survival by upregulating of autophagy via AMPK/mTORRat cerebral infarction modelUmbilical cord (human)2020Sun et al. [56]
Oncostatin MPromoting migration ability of MSCs by upregulating SDF-1Rat cerebral infarction modelBone marrow (rat)2019Han et al. [66]
TetramethylpyrazinePromoting cell homing by CXCL12/CXCR4 signaling pathway.Rat cerebral infarction modelBone marrow (rat)2019Li et al. [53]
MinocyclineUpregulating NeuN and VEGF in ischemic area boundaryRat cerebral infarction modelBone marrow (human)2018Cho et al. [58]
Mannitol and temozolomideIncreasing the BBB permeabilityRat cerebral infarction modelUmbilical cord (human)2018Choi et al. [68]
Stroke patient serumPromoting neurogenesis and angiogenesisRat cerebral infarction modelBone marrow (human)2018Moon et al. [72]
Palmitic acid-peptidePromoting migration ability of MSCsRat cerebral infarction modelBone marrow (rat)2017Huang et al. [67]
TetramethylpyrazinePromoting survival of MSCs against H2O2-induced apoptosis by PI3K/AKT and ERK1/2 pathwaysCell model of cerebral ischemiaBone marrow (rat)2017Fang et al. [52]
Valproate and lithiumPromoting cell homing and migration ability by activating CXCL12/CXCR4 and MMP9Rat cerebral infarction modelNot mentioned2011Tsai et al. [60]