|
| Genetic modification approaches | Possible mechanisms | Animal model | Source of MSC | Research time | References |
|
| FGF-21 overexpression | Improving the survival of MSCs and reducing apoptosis | Cell oxidative stress and inflammation model | Bone marrow (mice) | 2020 | Linares et al. [99] |
| Neurogenin-1 overexpression | Increasing the homing ability and engraftment efficiency of MSCs | Rat cerebral infarction model | Bone marrow (human) | 2020 | Kim et al. [87] |
| Immortalized by human telomerase reverse transcriptase | Reducing apoptosis in brain | Rat cerebral infarction model | Bone marrow (human) | 2019 | Li et al. [108] |
| SNHG12 silencing | Promoting the cell proliferation and reduce apoptosis of brain microvascular endothelial cells | Rat cerebral infarction model | Bone marrow | 2019 | Li et al. [114] |
| CCR2-overexpression | Promoting migration ability of MSCs | Rat cerebral infarction model | Bone marrow (human) | 2018 | Huang et al. [90] |
| HIF-1α gene-modified | Promoting viability, suppressing apoptosis, and activating autophagy-related signaling pathway | Rat cerebral infarction model and cell OGD model | Bone marrow (rat) | 2017 | Lv et al. [95, 96] |
| VEGF gene-modified | Improving the survival of MSCs, increasing expression and secretion of VEGF and BDNF | Rat cerebral infarction model | Bone marrow | 2017 | Zong et al. [137] |
| CX3CL1 gene-modified | Promoting migration ability of MSCs | Rat cerebral infarction model | Bone marrow (rat) | 2015 | Zhang et al. [89] |
| MiR-133b gene-modified | Exosomes from MSCs mediating the miR-133b transfer to astrocytes and neurons | Rat cerebral infarction model | Bone marrow (rat) | 2013 | Xin et al. [112] |
| SVV gene-modified | Improving the survival of MSCs and upregulating the expression of protective cytokines | Rat cerebral infarction model | Bone marrow (rat) | 2011 | Liu et al. [103] |
| Erythropoietin-transduced | Improving the survival of MSCs | Rat cerebral infarction model | Bone marrow (human) | 2010 | Cho et al. [106] |
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