Epicardially Placed Bioengineered Cardiomyocyte Xenograft in Immune-Competent Rat Model of Heart Failure

Figure 3

Cardiac histopathology. Representative left ventricular histopathology sections from 4 unique CHF rats (panels a–d) and 4 unique graft-treated rats (panels e–h). Masson’s Trichrome stain was performed on 5 μm transverse sections at the level of the papillary muscles. Micrographs (0.6x) have a 2 mm scale bar for reference. CHF rats exhibit large transmural scars in addition to dilated ventricular cavities, as anticipated with the adverse remodeling from heart failure. Graft-treated hearts exhibit increased wall thickness and increased myocyte density in the previously infarcted region. They also exhibit smaller ventricular cavities compared to the CHF controls.