Epicardially Placed Bioengineered Cardiomyocyte Xenograft in Immune-Competent Rat Model of Heart Failure

Figure 6

Unipolar electrograms from engineered graft. Superimposed colorized tracings depicting unipolar voltage electrograms (UVE) acquired utilizing a multielectrode array on one engineered cardiac graft. The black tracing exhibits the control depolarization (QS wave) and repolarization (T wave) waveforms via UVE collected without any pharmacologic manipulation. The blue tracing exhibits a UVE obtained from the same engineered graft exposed to isoproterenol (1-2 M); a physiologic shortening of the QS-QS interval and QT interval is observed. The red tracing exhibits a UVE obtained from the same engineered graft exposed to timolol (1-4 M); a physiologic lengthening of the QS-QS interval and QT interval is observed.