Palmitic Acid Methyl Ester Enhances Adipogenic Differentiation in Rat Adipose Tissue-Derived Mesenchymal Stem Cells through a G Protein-Coupled Receptor-Mediated Pathway

Figure 6

Schematic representation of the PAME-enhanced adipogenic differentiation in rAD-MSCs. PAME stimulated the GPR40 and GPR120, subsequently activating PLC, which in turn caused IP₃ generation, thereby leading to ERK1/2 activation through increases of intracellular Ca²⁺ levels, and eventually increased the expression of adipogenic differentiation genes, Pparγ and Gpd1.