SOX12 Promotes Stem Cell-Like Phenotypes and Osteosarcoma Tumor Growth by Upregulating JAGGED1

Figure 4

SOX12 downregulation inhibits the stem cell-like properties of osteosarcoma cells. (a) SOX12 knockdown inhibits the spheroidizing ability of 143B cells. (b) SOX12 knockdown reduces stemness marker expression in 143B cells. (c) SOX12 knockdown inhibits spheroidizing abilities in U2OS cells. (d) SOX12 knockdown reduces stemness marker expression in U2OS cells. (e–g) SOX12 knockdown inhibits tumor size and numbers in nude mice. , , .

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