SOX12 Promotes Stem Cell-Like Phenotypes and Osteosarcoma Tumor Growth by Upregulating JAGGED1

Figure 7

JAGGED1 downregulation inhibits the stem cell-like properties of osteosarcoma cells. (a) JAGGED1 knockdown reduced its mRNA expression. (b, c) JAGGED1 knockdown reduces stemness marker levels in osteosarcoma cells. (d, e) JAGGED1 knockdown inhibits the spheroidizing ability of osteosarcoma cells. (f–h) JAGGED1 knockdown inhibits tumor size and numbers in nude mice. , , , .

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