Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease

Figure 4

ICA treatment promotes transplanted NSCs differentiated into neurons in the FFT rat model. Double immunofluorescent staining of BrdU and NF-200 was applied to detect the number of neurons differentiated from NSCs of the NSC transplantation group (a) and group (b). Scale (A1–3, B1–3); 25 μm (A4, B4). (c) Quantitative analysis of the number of NF-200(+)- and BrdU(+)-positive cells in vivo. (d) Quantitative analysis of the percentage of BrdU(+)/NF200(+) cells to BrdU(+) cells in vivo. Data are expressed as the , . and , the group vs the NSC transplantation group.

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