Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease

Figure 5

ICA treatment increased the total number of astrocytes differentiated from transplanted NSCs in the FFT rat model. Double immunofluorescent staining of BrdU and GFAP was applied to detect the number of astrocytes differentiated from NSCs of the (a) NSC transplantation group and (b) group. Scale (A1–3, B1–3); 25 μm (A4, B4). (c) Quantitative analysis of the number of GFAP(+)- and BrdU(+)-positive cells in vivo. (d) Quantitative analysis of the percentage of BrdU(+)/GFAP(+) cells to BrdU(+) cells in vivo. Data are expressed as the , . and , the group vs the NSC transplantation group.

(a)

(b)

(c)

(d)