Research Article
Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Deliver miR-21 to Promote Corneal Epithelial Wound Healing through PTEN/PI3K/Akt Pathway
Figure 6
miR-21 regulates HCECs’ proliferation and migration by activating PI3K/Akt pathway through targeting PTEN. (a, d) HUMSC-sEV treatment decreased the RNA and protein levels of PTEN in HCECs. (b) The expression level of miR-21 in HCECs. (c, f) The PTEN changed with miR-21 variation. (e) The expression of phospho-Akt after overexpression of PTEN. (g) The expression level of phospho-Akt after transfected with miR-21 mimics was detected by Western blot. Data are expressed as the . , , and .
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |
(g) |