Advance of Mesenchymal Stem Cells in Chronic End-Stage Liver Disease Control

Table 2

Clinical trials registered at https://clinicaltrials.gov of MSCs in the treatment of the chronic end-stage liver diseases (of the approximately 1,348 clinical trials for liver fibrosis/cirrhosis, 68 were MSC-based cell therapy clinical trials; the data comes from https://clinicaltrials.gov and the top 29 most recent studies are listed with the highest correlation).

NCT number	Title	Status	Conditions	Interventions	Phase
NCT01220492	Umbilical Cord Mesenchymal Stem Cells for Patients with Liver Cirrhosis	Completed	Liver cirrhosis	(i) Drug: conventional plus UCMSC treatment; (ii) Drug: conventional plus placebo treatment	Phase 1; Phase 2
NCT03529136	Clinical Trial of Umbilical Cord Mesenchymal Stem Cell Transfusion in Decompensated Liver Cirrhosis	Unknown	Decompensated liver cirrhosis	Biological: UCMSCs	Phase 2
NCT03254758	A Study of ADR-001 in Patients with Liver Cirrhosis	Recruiting	Decompensated liver cirrhosis	Biological: ADMSCs	Phase 1; Phase 2
NCT03626090	Mesenchymal Stem Cell Therapy for Liver Cirrhosis	Recruiting	Liver cirrhosis	Biological: autologous BMMSCs	Phase 1; Phase 2
NCT02786017	Injectable Collagen Scaffold™ Combined with HUC-MSCs Transplantation for Patients with Decompensated Cirrhosis	Unknown	Decompensated liver cirrhosis	(i) Biological: conventional therapy; (ii) Biological: injectable collagen scaffold+human UCMSCs	Phase 1; Phase 2
NCT03460795	Safety and Efficacy Study of Cotransferring of Mesenchymal Stem Cell and Regulatory T Cells in Treating End-Stage Liver Disease	Not yet recruiting	Liver cirrhosis	Biological: MSC and regulatory T cells	Phase 1; Phase 2
NCT05080465	Long-Term Follow-up Mesenchymal Stem Cell Therapy for Patients Virus-Related Liver Cirrhosis	Active, not recruiting	Liver cirrhosis	Biological: autologous BMMSCs	Phase 3
NCT03838250	Study to Evaluate Hepatic Artery Injection of Autologous Human Bone Marrow-Derived MSCs in Patients with Alcoholic LC	Recruiting	Alcoholic liver cirrhosis	Biological: Cell gram™ (BMMSCs)	Phase 1
NCT05121870	Treatment With Human Umbilical Cord-Derived Mesenchymal Stem Cells for Decompensated Cirrhosis	Recruiting	Decompensated liver cirrhosis	(i) Biological: UCMSCs; (ii) Biological: saline containing 1% human serum albumin (solution without UCMSCs)	Phase 2
NCT03209986	Trial of Mesenchymal Stem Cell Transplantation in Decompensated Liver Cirrhosis	Unknown	Liver cirrhosis	(i) Procedure: MSC transplantation via peripheral vein; (ii) Other: MSCs	Not applicable
NCT04243681	Combination of Autologous MSC and HSC Infusion in Patients with Decompensated Cirrhosis	Completed	Liver cirrhosis	(i) Combination product: CD34+ cells and MSC infusion; (ii) Drug: standard of care for cirrhosis management	Phase 4
NCT01342250	Human Umbilical Cord Mesenchymal Stem Cells Transplantation for Patients with Decompensated Liver Cirrhosis	Completed	Liver cirrhosis	(i) Biological: conventional therapy plus low-dose human UCMSC treatment; (ii) Biological: conventional therapy plus medium-dose human UCMSC treatment; (iii) Biological: conventional therapy plus high-dose human UCMSC treatment	Phase 1; Phase 2
NCT03945487	Mesenchymal Stem Cells Treatment for Decompensated Liver Cirrhosis	Recruiting	Decompensated liver cirrhosis	(i) Biological: UCMSCs; (ii) Other: comprehensive treatment	Phase 2
NCT05106972	Umbilical Cord Mesenchymal Stem Cell Transplantation for Decompensated Hepatitis B Cirrhosis	Recruiting	Liver cirrhosis	Drug: UCMSC infusion	Not applicable
NCT01233102	Mesenchymal Stem Cells Treat Liver Cirrhosis	Suspended	Liver cirrhosis	(i) Drug: conserved therapy; (ii) Procedure: hepatic artery UCMSC infusion or intravenous infusion	Phase 1; Phase 2
NCT04522869	Umbilical Cord Derived Mesenchymal Stem Cell (UC-MSC) Transplantation for Children Suffering from Biliary Atresia	Recruiting	Primary biliary cirrhosis	Biological: UCMSC transplantation	Phase 1; Phase 2
NCT04357600	Umbilical Cord Mesenchymal Stem Cell for Liver Cirrhosis Patient Caused by Hepatitis B	Recruiting	Liver cirrhosis	Biological: allogeneic UCMSCs	Phase 1; Phase 2
NCT01454336	Transplantation of Autologous Mesenchymal Stem Cell in Decompensate Cirrhotic Patients with Pioglitazone	Completed	Liver fibrosis	Biological: MSC injection	Phase 1
NCT05331872	Umbilical Cord-Derived Mesenchymal Stem Cell Infusion in the Management of Adult Liver Cirrhosis	Recruiting	Liver cirrhosis	Biological: human UCMSC infusion	Phase 1
NCT05227846	Human Umbilical Cord-Derived Mesenchymal Stem Cells for Decompensated Cirrhosis (MSC-DLC-1)	Not yet recruiting	Decompensated liver cirrhosis	Biological: human UCSMCs	Phase 1
NCT05224960	Human Umbilical Cord-Derived Mesenchymal Stem Cells for Decompensated Cirrhosis (MSC-DLC-2)	Not yet recruiting	Decompensated liver cirrhosis	(i) Biological: UCMSCs; (ii) Biological: placebo (solution without UCMSCs)	Phase 2
NCT02943889	Stem Cell Transplantation in Cirrhotic Patients	Unknown	Liver cirrhosis	Biological: MSC transplantation	Phase 1; Phase 2
NCT02705742	Mesenchymal Stem Cells Transplantation for Liver Cirrhosis Due to HCV Hepatitis	Unknown	Liver cirrhosis	Biological: autologous ADMSCs	Phase 1; Phase 2
NCT02652351	Human Umbilical Cord-Mesenchymal Stem Cells for Hepatic Cirrhosis	Unknown	Liver cirrhosis	Biological: human UCMSCs	Phase 1
NCT01728727	Safety and Efficacy of Human Umbilical Cord-Derived Mesenchymal Stem Cells for Treatment of HBV-Related Liver Cirrhosis	Unknown	(i) Liver cirrhosis; (ii) End-stage liver diseases	(i) Other: UCMSC transplantation; (ii) Other: conventional treatment	Phase 1; Phase 2
NCT01662973	Umbilical Cord Mesenchymal Stem Cells for Patients with Primary Biliary Cirrhosis	Unknown	Primary biliary cirrhosis	(i) Other: conventional plus UCMSC treatment; (ii) Other: conventional plus placebo treatment	Phase 1; Phase 2
NCT01741090	The Effectiveness and Safety for Mesenchymal Stem Cell for Alcoholic Liver Cirrhosis	Unknown	Alcoholic liver cirrhosis	Biological: BMMSC injection	Phase 2
NCT01483248	Human Menstrual Blood-Derived Mesenchymal Stem Cells for Patients with Liver Cirrhosis	Unknown	(i) Liver cirrhosis; (ii) Liver fibrosis; (iii) Liver diseases; (iv) Digestive system diseases	(i) Biological: conventional therapy plus MSC transplantation; (ii) Drug: conventional therapy plus placebo treatment	Phase 1; Phase 2
NCT01440309	Efficacy and Safety Study of Allogenic Mesenchymal Stem Cells for Patients with Refractory Primary Biliary Cirrhosis	Unknown	Primary biliary cirrhosis	(i) Biological: BMMSC; (ii) Drug: ursodeoxycholic acid	Phase 1