Preclinical Evaluation of the Tumorigenic and Immunomodulatory Properties of Human Bone Marrow Mesenchymal Stromal Cell Populations with Clonal Trisomy 5

Table 1

Cytogenetic characterization by karyotype and CMA of human bone marrow MSC samples included in the study.

MSC sample	Karyotype (number of metaphases)	Passage at karyotyping	CMA	Passage at CMA
M10	46,XX[15]/44,XX,-8,17[1]/ 45,XX,-5[1]/44,XX,-5,-18[1]/ 45,XX,-22[1]/45,XX,-21[1]	9	arr(1-22,X)x2	9
M12	46,XY[19]/44,X,-10[1]	10	arr(1-22)x2, (XY)x1	10
T5-50	46,XX[18]/47,XX,+5[2]	4	NA	---
T5-53	46,XX[14]/47,XX,+5[6]	6	arr(X)×2,(5)×3 [0.1]	9

Nomenclature according to International System for Human Cytogenomic Nomenclature (ISCN, 2016). NA: not available (due to low number of viable cells after cell culture).