Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening

Figure 2

The body-on-a-chip-based drug screening flowchart. The different tissues/organs-specific organoids were arranged in order with BBB organoids in the first place followed by cerebral organoids and other organoids that recapitulate their corresponding tissues/organs in a body-on-a-chip device. Several successive screening processes could be conducted starting from the primary screening to identify the compounds that could pass the blood-brain-barriers (BBB) followed by the second and third rounds of screenings to identify the compound hits that are toxic to neurons and that could rescue neurodegenerations, respectively.