miR-31 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviates Intervertebral Disc Degeneration by Inhibiting NFAT5 and Upregulating the Wnt/<i>β</i>-Catenin Pathway

<div>Schematic diagram of the mechanism by which miR-31 in hBMSC-EVs affects IDD. hBMSC-EVs transferred miR-31 to NPCs where miR-31 targets NFAT5 and reduces the expression of NFAT5 and activates the Wnt/<i>β</i>-catenin pathway, thus promoting the proliferation of NPCs, inhibiting their apoptosis, and reducing the release of cellular inflammatory factors, ultimately alleviating IDD in mice.</div>

Stem Cells International

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Figure 9

Figure 9: miR-31 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviates Intervertebral Disc Degeneration by Inhibiting NFAT5 and Upregulating the Wnt/<i>β</i>-Catenin Pathway 

Figure 9 | miR-31 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviates Intervertebral Disc Degeneration by Inhibiting NFAT5 and Upregulating the Wnt/β-Catenin Pathway 