FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A

<div>FBXW7 inhibits the tumorigenesis <i>in vivo</i> and interferes with sorafenib resistance of HCC cells. (a) Images of xenografts in nude mice 6 weeks after subcutaneous injection of indicated cells. (b, c) Xenograft tumors growth curve and weight. 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(e) FBXW7 overexpression increased the sensitivity to sorafenib, while FBXW7 knockdown reduced the sensitivity to sorafenib. (f) The influence of FBXW7 or sorafenib on the sphere formation in MHCC-97H or Huh7 cells. 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Stem Cells International

fig3

Figure 3

Figure 3: FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A 