FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A

<div>FBXW7 regulates ACTL6A expression levels to inhibit HCC growth <i>in vivo</i> and resistance of sorafenib <i>in vitro</i>. (a–c) The indicated engineered MHCC-97H or control cells were injected into subcutaneous and representative images of tumors (a), tumor growth curve (b), and tumor weight (c). (d) The expression of ACTL6A, CD133, Nanog, and OCT in xenograft tumor tissues by IHC staining. (e) Overexpression of ACTL6A in MHCC-97H decreased the sensitivity to sorafenib, which was rescued by FBXW7 upregulation. (f) Effect of ACTL6A overexpression combined with sorafenib on tumor spheroid formation in MHCC-97H cells. 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Stem Cells International

fig8

Figure 8

Figure 8: FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A 