Chidamide Suppresses the Growth of Cholangiocarcinoma by Inhibiting HDAC3 and Promoting FOXO1 Acetylation

Figure 6

CDM retards the growth of CCA in nude mice by regulating the HDAC3/FOXO1 axis. (a) Tumor volume of mice treated with CDM-H or combined with oe-HDAC3. (b) The distribution of CDM in the tumor and major organs of mice treated with CDM-H or combined with oe-HDAC3. (c) Representative images showing xenografts in nude mice and H&E staining of tumor tissues of mice treated with CDM-H or combined with oe-HDAC3. (d) Western blotting of HDAC3 protein and FOXO1 acetylation level in tumor tissues of mice treated with CDM-H or combined with oe-HDAC3. , compared with oe-NC-treated mice. ^#, compared with CDM-H-treated mice. Data are shown as the . One-way ANOVA with Tukey’s post hoc test was used for multigroup data comparison and repeated measures ANOVA with Tukey’s post hoc test was applied to compare data at different time points. for mice in each group.

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