Wharton’s Jelly-Derived Mesenchymal Stem Cells with High Aurora Kinase A Expression Show Improved Proliferation, Migration, and Therapeutic Potential

Figure 7

Both AURKA and DOCK2 contributed to cell proliferation and migration of WJ-MSCs, and AURKA of WJ-MSCs inhibited apoptosis in mdx mouse through XCL1. (a) In WJ-MSCS, both AURKA and DOCK2 promoted the proliferation and migration of WJ-MSCs through phosphorylation of kinases. (b) In WJ-MSCs, AURKA stimulated XCL1 transcription, causing XCL1 secretion from WJ-MSCs. The secreted XCL1 bound to the chemokine receptors of muscle cells, thereby inhibiting the cleavage of caspase-3 and PARP and suppressing the apoptosis of muscle cells.

(a)

(b)