Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells

Figure 5

The dynamic and reversible processes of m6A methylation. m6A RNA methylation is mainly regulated by its “writers,” “erasers,” and “readers.” Writers refer to the m6A methylase complex including METTL3, METTL14, and WTAP. Erasers are m6A demethylases involving FTO and ALKBH5. Readers include the YTH domain family (YTHDFs and YTHDCs) and IGF2BP1/2/3 family. “Writers” deposit m6A methylation on RNAs, while “erasers” remove the m6A marks. “Readers” can directly bind to m6A to mediate downstream processes including mRNA export and mRNA translation.