Review Article
Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells
Table 1
Methylation and demethylation in PDLSCs.
| Methylated modification | Epigenetic modifiers | Epigenetic marks | Functions |
| DNA methylation | RG108 | DNMT inhibitor | The hypomethylation of RUNX2 promoted osteogenic potential [116]. | 5-Aza | DNMT inhibitor | Down-regulating expression of DNMT1, stimulating osteogenic differentiation [108, 113, 115, 117, 118]. | SAM | Methyl-donor | Rescuing the cell viability and increasing the methylation of TNFR-1 [118]. | DNA demethylation | TET1/2 | DNA demethylases | Enhancing differentiation while inhibiting immune regulation [119ā122, 129]. | Histone methylation | EZH2 | H3K27me3 | Inhibiting the osteogenic differentiation [110, 123, 124, 129]. | SETD1B | H3K4me3 | Downregulating the release of inflammatory factors from PDLSCs stimulated by LPS [125]. | SETD2 | H3k36me3 | Promoting the osteogenic differentiation [126]. | Histone demethylation | KDM6A | H3K27me3, H3K4me3 | Enhancing the osteogenic differentiation [22, 127]. | EPZ-6438 | EZH2 inhibitor | Rescuing the chondrogenic potential of PDLSCs by decreased H3K27me3 [22]. | KDM6B | H3K27 | Enhancing periodontitis inflammatory response and apoptosis [124, 128]. | | H3K4me3 | Promoting potential of proliferation, chemotaxis and migration [109]. |
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