Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells

Table 3

Methylation and demethylation in DFSCs.

Methylated modification	Epigenetic modifiers	Epigenetic marks	Functions
DNA methylation	DNMT1	DNA methyltransferases	Inhibiting osteogenesis [78, 166].
	5-Aza	DNMT inhibitor	Promoting osteogenesis [78, 166].
Histone methylation		H3K4me3, H3K9me3	H3K4me3 marker will switch to the H3K9me3 marker during osteogenic differentiation [167].
	EZH2	H3K27me3	EZH2 inhibits the osteogenesis of DFSCs by reducing H3K27me3 expression of Wnt gene promoter [111, 150, 168].