Review Article
Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells
Table 3
Methylation and demethylation in DFSCs.
| Methylated modification | Epigenetic modifiers | Epigenetic marks | Functions |
| DNA methylation | DNMT1 | DNA methyltransferases | Inhibiting osteogenesis [78, 166]. | 5-Aza | DNMT inhibitor | Promoting osteogenesis [78, 166]. | Histone methylation | | H3K4me3, H3K9me3 | H3K4me3 marker will switch to the H3K9me3 marker during osteogenic differentiation [167]. | EZH2 | H3K27me3 | EZH2 inhibits the osteogenesis of DFSCs by reducing H3K27me3 expression of Wnt gene promoter [111, 150, 168]. |
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