Review Article
Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells
Table 4
Methylation and demethylation in SCAPs.
| Methylated modification | Epigenetic modifiers | Epigenetic marks | Functions |
| Histone demethylation | KDM2A | H3K36me2, H3K4me2 | Inhibiting osteogenic differentiation [172ā177]. | KDM3B | H3K9me2 | Exerting a positive impact on osteogenic differentiation of SCAPs and regulating the cell cycle to accelerate the proliferation of SCAPs [178]. | KDM1A | H3K4me2/1, H3K9me2/1 | KDM1A forms a protein complex with PLOD2 to inhibit the bone-dentin differentiation [179]. | MLL | H3K4me3 | Promoting odontogenic differentiation of SCAPs by upregulating Wnt5a [182]. | KDM6B | H3K27me3 | Loss of the demethylase KDM6B increases H3K27me while inhibits odontogenic differentiation [182]. |
|
|