Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells

Table 4

Methylation and demethylation in SCAPs.

Methylated modification	Epigenetic modifiers	Epigenetic marks	Functions
Histone demethylation	KDM2A	H3K36me2, H3K4me2	Inhibiting osteogenic differentiation [172–177].
	KDM3B	H3K9me2	Exerting a positive impact on osteogenic differentiation of SCAPs and regulating the cell cycle to accelerate the proliferation of SCAPs [178].
	KDM1A	H3K4me2/1, H3K9me2/1	KDM1A forms a protein complex with PLOD2 to inhibit the bone-dentin differentiation [179].
	MLL	H3K4me3	Promoting odontogenic differentiation of SCAPs by upregulating Wnt5a [182].
	KDM6B	H3K27me3	Loss of the demethylase KDM6B increases H3K27me while inhibits odontogenic differentiation [182].