Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4⁺ T-Cell Activity by Transferring UCA1 and Targeting LAMC2

Figure 5

OSCC-CSC-derived sEVs transferring UCA1 accelerate M2 macrophage polarization and enhance the tumorigenicity of OSCC xenografts in nude mice. (a) Tumor volume curve and (b) tumor weight of nude mice () in different treatment groups. (c) Detection of CD206⁺CD11b⁺ M2 macrophages in the tumor tissues of nude mice, determined by flow cytometry in different treatment groups. (d) Detection of IFN-γ⁺CD4⁺ T cells among the spleen cells in nude mice, determined by flow cytometry in different treatment groups. , ^#. The data in the figure were measurement data from 6 mice, which summarized as .

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