Mesenchymal Stem Cells May Alleviate the Intervertebral Disc Degeneration by Reducing the Oxidative Stress in Nucleus Pulposus Cells
Table 2
Detailed information of top 10 hub OSRDEGs.
Gene symbols
Full names
Gene function
Log2 (fold change)
value
Regulation
JUN
Jun proto-oncogene
This gene encodes a protein which can regulate the gene expression via interacting directly with specific target DNA sequences.
-1.03
<0.01
Down
CAT
Catalase
This gene encodes the catalase, which is an important antioxidant enzyme in the bodies against the oxidative stress.
0.62
<0.01
Up
PTGS2
 Prostaglandin-endoperoxide synthase 2
The protein encoded by this gene is a vital enzyme in the process of prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase.
-1.12
<0.01
Down
TLR4
Toll like receptor 4
The protein encoded by this gene is a member of the toll-like receptor family, which is involved in the pathogen recognition and activation of inherent immunity.
-0.88
<0.01
Down
FOS
Fos proto-oncogene
This gene encodes one member of leucine zipper proteins that can dimerize with proteins of the JUN family to form the transcription factor complex AP-1.
-1.63
<0.01
Down
APOE
Apolipoprotein E
The protein encoded by this gene is a major apoprotein of the chylomicron, which is indispensable for the catabolism of triglyceride-rich lipoprotein constituents.
1.19
<0.01
Up
EDN1
Endothelin 1
This gene encodes a preproprotein that is proteolytically processed to produce a secreted peptide. This gene is involved with the tumorigenesis and pulmonary arterial hypertension.
-2.08
<0.01
Down
TXNRD1
Thioredoxin reductase 1
The protein encoded by this gene is a member of the pyridine nucleotide-disulfide oxidoreductase family, and the thioredoxin system.
-0.69
<0.01
Down
LRRK2
Leucine rich repeat kinase 2
This gene is a member of the leucine-rich repeat kinase family, and the dysregulated expression of this gene may lead to the Parkinson disease-8.
-1.09
<0.01
Down
KLF2
Kruppel like factor 2
The protein encoded by this gene is a member of Kruppel family of transcription factors. It plays an important role in the adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability.
