Research Article

Asymptomatic Hyperuricemia Is Associated with Achilles Tendon Rupture through Disrupting the Normal Functions of Tendon Stem/Progenitor Cells

Figure 5

Analysis of the transcriptome and protein expressions in TSPCs treated with different concentrations of UA. (a) Heat map visualization of DEG between TSPCs exposed to UA at the physiological level (0.2 mM) and the level corresponding to hyperuricemia (0.8 mM) for 48 h. (b) GO enrichment of gene sets from TSPCs impacted by hyperuricemia. (c) Cell lysates of TSPCs treated with PBS or various doses of UA for 48 h were tested for the AKT-mTOR pathway, the autophagy markers, and c-Jun activation by Western blot analysis. Results are representative of at least 3 independent experiments.