Research Article
Exosomes Derived from Runx2-Overexpressing BMSCs Enhance Cartilage Tissue Regeneration and Prevent Osteoarthritis of the Knee in a Rabbit Model
Figure 1
Characterizations of bone marrow mesenchymal stem cells (BMSCs) and chondrocytes, Original magnification, ×100. (a) BMSCs displayed a representative spindle-like morphology. (b) BMSCs exhibited multipotential differentiation for osteogenesis, adipogenesis, and chondrogenic. (c) BMSCs’ surface markers proteins (CD29, CD44, and CD45) determined by flow cytometric. (d) Chondrocytes displayed a triangular or polygonal at the 3rd day. (e) Chondrocytes grew and displayed a “paving stone” shape at the 7rd day. (f) Chondrocytes matrix with refracted light was visible around the chondrocytes. (g–i) Chondrocytes was confirmed by staining of acridine orange fluorescence, toluidine blue, and immunofluorescence. This experiment was repeated independently three times.
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