Tailored Extracellular Vesicles: Novel Tool for Tissue Regeneration

Table 2

Modified EVs in the therapy eye-related diseases.

Diseases	EV Sources	Specific substrates	Modification methods	Modified EVs	Biological effects	Ref.
Pathological retinal angiogenesis	EC	Anchoring peptide CP05; KV11 peptide	Link therapeutic peptide to EV via anchoring peptide	KV11-CP05-EV	Less neovascularization and vessel leakage	[62]
CNV	Treg	VEGF antibody	Conjugate antibody to EV via a peptide linker (cL)	CL-aV-EV	Inhibition of inflammation and VEGF activity	[63]