Review Article
Tailored Extracellular Vesicles: Novel Tool for Tissue Regeneration
Table 6
Modified EVs in the therapy of diabetes and its complication.
| | Diseases | EV Sources | Specific substrates | Modification methods | Modified EVs | Biological effects | Ref. |
| | Diabetes | BMDM | miR-690 | Cell transfection | miR-690-EV | Glucose tolerance and insulin sensitivity | [126] | | Diabetes | Serum | BAY55-9837 peptide; SPIONs | Electroporation; magnetic particles | SPION-BAY-EV | Targeted delivery of BAY55-9837; increase insulin secretion | [127] | | DN | BMSC | miR-let-7a | Cell transfection | miR-let-7a-EV | Antiapoptosis | [130] | | DPN | BMSC | miR-146a | Cell transfection | miR-146a-EV | Reduce neurovascular damage | [133] | | DPN | BMSC | PpyNps containing liposomes | Hybrid nanovesicles | PpyNps-hybrid nanovesicles | Provide electrical cues; Synergetic regenerative effect | [134] |
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