Tailored Extracellular Vesicles: Novel Tool for Tissue Regeneration

Table 7

Modified EVs in the therapy of renal injury.

Diseases	EV Sources	Specific substrates	Modification methods	Modified EVs	Biological effects	Ref.
AKI	Fibroblast	Klotho	Exo-Fect agent	Klotho-EV	Renoprotective effects	[140]
AKI	PL-MSC	RGD hydrogels	Biomaterials	RGD hydrogel-EV	Augment retention and stability of EVs and treatment efficacy	[146]
Renal fibrosis	BMSC	miR-let7c	Cell transfection	miR-let7c-EV	Antifibrosis	[141]
CKD	Satellite cell	miR-29	Cell transfection	miR-29-EV	Antifibrosis	[142]