Human Placental Mesenchymal Stem Cells for the Treatment of ARDS in Rat

Figure 3

Histological changes in lung tissue after ARDS modeling and treatment. (a) LPS and the (b) LPS+dexamethasone groups. Structural lung damage, edema, alveolar hemorrhage, and (e) inflammatory cell infiltration. H&E staining ×200. Observation period 48 hours; (c) LPS+HPMSC and (d) HPMSC groups. The mild edema and infiltration of the lung tissue with inflammatory cells. Observation period 48 hours. H&E staining ×200; (f) LPS and the LPS+dexamethasone groups. Neutrophils (red arrows), (g) giant cells (green arrows), and (h) a large number of alveolar macrophages were noted in the alveolar space. Observation period 96 hours. H&E staining ×800; (i) LPS group. Destruction of lung tissue. H&E staining ×200. (j) LPS+dexamethasone group. Thickening of the alveolar septa. H&E staining ×400; (k) LPS+HPMSC group. A slight thickening of the alveolar septum. H&E staining ×200; (l) the HPMSC group. A solid structure, clear alveolar space without congestion in the alveolar wall. H&E staining ×200. Observation period one week.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)