Intracerebral Transplantation of Mesenchymal Stromal Cell Compounded with Recombinant Peptide Scaffold against Chronic Intracerebral Hemorrhage Model

Figure 3

rCellSaic was associated with better neurological recovery, release of more trophic factors, and better cell engraftment after transplantation. The animals that received rCellSaic showed significantly better neurological recovery at 3 and 4 weeks after transplantation than the animals that received solo-rBMSC or saline (a). The cerebral local BDNF levels around ICH were compared three days after transplantation, and the rCellSaic group showed a significantly higher amount of BDNF compared with the saline group, and showed a higher trend than the rBMSC group (b). rBMSC derived from CellSaics engrafted in the host brain around the hollow cavity 4 weeks after the transplantation (c; left), whereas the cells could not be detected in the rBMSC groups (c; right) (magnification, ×400; ). Data are presented as the . # vs. saline group; vs. rBMSC group; vs. rBMSC group (the Kruskal–Wallis test followed by the Steel–Dwass test).

(a)

(b)

(c)