Intracerebral Transplantation of Mesenchymal Stromal Cell Compounded with Recombinant Peptide Scaffold against Chronic Intracerebral Hemorrhage Model

Figure 5

rCellSaics transplantation ameliorated neuronal integrity damage. Neuronal integrity was assessed by ^I-123-iomazenil single-photon emission computed tomography. The radioactivity ratios were calculated, and their variation from 1 week to 4 weeks after transplantation in the rBMSC and rCellSaic groups was compared with respect to the maximum injured area of ICH (4 mm posterior to the bregma) (a) and the marginal area of ICH (2 mm posterior to the bregma) (b). While there was no difference in the radioactivity ratio variation between the two groups at the maximum injured area, the radioactivity ratio variation in the rCellSaic group showed a higher trend than that in the rBMSC group at the marginal area (b; arrow). The results indicate that benzodiazepine receptors were preserved or recovered at around the hematoma margin, which represents the neuro-integrity preservation potential of CellSaic. Data are presented as the (the Wilcoxon rank sum test).

(a)

(b)