Mechanical Cues Regulate Histone Modifications and Cell Behavior

Table 4

Examples of nanotopography-regulated histone modifications.

Cell type	Nanotopography	Epigenetic modification	Function	Ref
hASC	Nanotube array	HDAC	Promote osteogenic differentiation	[51]
Fibroblast	Microgroove	HDAC	Facilitate IPSC reprogramming	[53]
BMSC	Microgroove	HDAC	Not tested in research	[55]
Fibroblast	Microgroove	H3K4me3	Promote induced dopaminergic neuron reprogramming	[54]
MSC	Micropatterning	H3K9ac, H3K9me3, H3K36me3	Increase MSC proangiogenic activity and increase angiogenesis	[57]
MCF7	Micropatterning	H3K9ac, H3K4me3, K27me3	Induce transcriptome change and nuclear reprogramming, increase cell stemness	[58]
Fibroblast	Tissue 3D constraints	HDAC and H3K9ac	Increase cell sensitivity to mechanostimulation, promote essential processes for cell rejuvenation	[52]
MIC	Micropatterning	H3K4me2 and H3K9ac	Upregulate PRDM14 gene and influence melanoma heterogeneity	[59]
Cardiac progenitors	Microgroove	Histone acetylation	Increase myocardin, tbx5, and mef2c expression	[56]

hASC: human adipose tissue-derived stem cell; BMSC: bone marrow mesenchymal stem cells; MIC: malignant melanoma-initiating cell.