Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting

Table 1

Similarities between NSCs and CSCs [5, 7, 9, 10].

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Common features associated with NSCs and CSCs

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(i) Unlimited proliferation potential and self-renewal property.

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(ii) Regulation of their self-renewability by using common signaling pathways like Wnt/β-catenin, Notch, and Shh.

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(iii) Expression of similar surface receptors such as CD133, CXCR4, and a6 integrin.

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(iv) Share same telomere-lengthening mechanisms for replicative ability.

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(v) Possess high nuclear to cytoplasmic ratio as well as increased expression of antiapoptotic genes.

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