Erythropoietin Activates Autophagy to Regulate Apoptosis and Angiogenesis of Periodontal Ligament Stem Cells via the Akt/ERK1/2/BAD Signaling Pathway under Inflammatory Microenvironment

<div>Identification of PDLSCs and establishment of inflammatory microenvironment. (a) Primary passage PDLSCs derived from periodontal ligament and the first passage PDLSCs digested from primary passage. (b) Observed osteogenic induction of PDLSCs under fluorescent inverted microscope. (c) Observed lipogenic induction of PDLSCs under fluorescent inverted microscope. (d) Flow cytometry detected cell surface marker (CD44, CD105, CD90, CD31, and CD45). (e) mRNA expression level of IL-1<i>β</i> and IL-8 compared to <i>β</i>-actin through qPCR. 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Stem Cells International

fig1

Figure 1

Figure 1: Erythropoietin Activates Autophagy to Regulate Apoptosis and Angiogenesis of Periodontal Ligament Stem Cells via the Akt/ERK1/2/BAD Signaling Pathway under Inflammatory Microenvironment 

Figure 1 | Erythropoietin Activates Autophagy to Regulate Apoptosis and Angiogenesis of Periodontal Ligament Stem Cells via the Akt/ERK1/2/BAD Signaling Pathway under Inflammatory Microenvironment 