|
| First author and publication year | Journal | Species | Sex | Sample size (MSCs/control) | HD model | Manipulation of MSCs | MSC source | MSC type | Age of donor | Passage of MSCs | MSC dose | Delivery route | Follow-up period | Outcomes |
|
| Bayat 2021 [12] | Journal of Chemical Neuroanatomy | Wistar rats | M | 20 (10/10) | 3-NP | None | OE-MSCs-human | Xenogeneic | 20- to 30-year-old human | Passage 3 | | Intra-striatum | 30 days | 1. Open field
2. Rotarod
3. Muscle activity latency
4. Volume of striatum |
|
| Yu-Taeger 2019 [16] | Cells | B6CBAF1/J mice | F | 32 (16/16) | R6/2 | None | BM-MSCs- C57Bl/6 | Allogeneic | 8- to 12-week-old mice | Passage 3 | | IN | 7.5 weeks | 1. Rotarod |
|
| Elbaz 2019 [17] | Neurochemistry International | Wistar rats | M | 24 (12/12) | 3-NP | None | BM-MSCs-Wistar | Allogeneic | NR | Passages 2-5 | | ITV | 24 hours | 1. Rotarod
2. Grip strength |
|
| Ebrahimi 2018 [18] | Neurotoxicity Research | SD rats | M | 20 (10/10) | 3-NP | None | UC-MSCs-human | Xenogeneic | Newborn human | Passage 4 | | Intra-striatum | 30 days | 1. Rotarod
2. Muscle activity latency
3. Volume of striatum |
|
| Linares 2016 [19] | Experimental Neurology | B6C3F1/J mice | M/F | 20 (10/10) | N171-82Q | None | BM-MSCs-C57Bl/6 | Allogeneic | ≤8-week-old mice | Passage 4-7 | | IN | 9 weeks | 1. Rotarod |
| 20 (10/10) | Lithium and valproic acid | 1. Rotarod |
|
| Rossignol 2015 [20] | Stem Cell Research & Therapy | C57BL/6 mice | M/F | 17 (7/10) | R6/2 | None | BM-MSCs-WT littermates | Syngeneic | 6- to 8-week-old mice | Passage 6 | | Intra-striatum | 6 weeks | 1. Rotarod
2. Morris water maze
3. Clasping
4. Area of total brain |
|
| Fink 2013 [21] | Stem Cell Research & Therapy | C57BL/6 mice | M/F | 21 (9/12) | R6/2 | None | UC-MSCs- C57Bl/6 | Allogeneic | 15-day-old mice | Passage 3-8 | | Intra-striatum | 6.5 weeks | 1. Rotarod
2. Morris water maze
3. Clasping
4. Area of total brain |
|
| Sadan 2012 [22] | Experimental Neurology | Wistar rats | M | 20 (10/10) | QA | None | BM-MSCs-human | Xenogeneic | Adult human | Passage 2-7 | | Intra-striatum | 42 days | 1. Apomorphine-induced rotation test
2. Volume of striatum |
| 21 (11/10) | Neurotrophic factors | 1. Apomorphine-induced rotation test
2. Volume of striatum |
|
| Sadan 2012 [23] | PLoS Currents Huntington Disease | C57BL/6 mice | NR | 13 (6/7) | R6/2 | None | BM-MSCs-human | Xenogeneic | Adult human | Passage 2-6 | | Intra-striatum | 10 weeks | 1. Rotarod |
| 14 (7/7) | Neurotrophic factors | 1. Rotarod |
|
| Moraes 2012 [24] | Stem Cell Research | Wistar rats | M | 8 (4/4) | QA | None | BM-MSCs-Wistar | Allogeneic | NR | NR | | Intra-striatum | 60 days | 1. Ventricular area |
|
| Lin 2011 [25] | PLoS One | C57BL/6 mice | M | 25 (16/9) | QA | None | BM-MSCs-human | Xenogeneic | NR | NR | | Intra-striatum | 13 weeks | 1. Volume of striatum
2. Rotarod |
|
| Im 2010 [26] | PLoS Currents Huntington Disease | C57BL/6 mice | NR | 15 (7/8) | YAC128 | None | AMSCs-human | Xenogeneic | NR | Passage 3 | | Intra-striatum | 4 months | 1. Rotarod
2. Volume of striatum |
|
| Edalatmanesh 2010 [27] | Neurological Research | Wistar rats | M | 16 (8/8) | QA | None | BM-MSCs-Wistar | Allogeneic | 3- to 4-month-old rats | Passage 3 | | IV | 9 weeks | 1. Apomorphine-induced rotation test
2. Hang wire test
3. Morris water maze |
|
| Lee 2009 [28] | Annals of Neurology | SD rats | M | 12 (6/6) | QA | None | AMSCs-human | Xenogeneic | NR | Passage 5 | | Intra-striatum | 4 weeks | 1. Apomorphine-induced rotation test |
| C57BL/6 mice | M/F | 12 (6/6) | R6/2 | None | | 1. Rotarod
2. Volume of striatum
3. Clasping
4. Ventricular area |
|
| Amin 2008 [29] | Neurological Research | Wistar rats | NR | 16 (8/8) | QA | None | BM-MSCs-Wistar | Allogeneic | 2-month-old rats | Passage 3 | | Intra-striatum | 9 weeks | 1. Volume of striatum
2. Ventricular area |
|
